My Research
Over the course of my graduate and post-doctoral training I have conducted biochemical and biological research aimed at validating novel targets for the treatment of diseases of oxidative stress. More specifically, my research has focused on the metabolism of Nicotinamide Adenine Dinucleotide (NAD), the bioactive form of the vitamin niacin, and the roles that NAD-derived molecules play in modulating cellular life/death decisions and inflammatory responses following oxidative stress. The figure below shows the NAD metabolome in mammalian cells, and introduces the pathways of NAD biosynthesis and metabolism that I am interrogating in an attempt to discover new therapies for the treatment of diseases as diverse as cancer, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), interstitial pulmonary fibrosis (IPF), Alzheimer's disease, and schistosomiasis.
For more information on my research and other projects in the laboratory of Frances E. Lund, please click here.
For more information on my research and other projects in the laboratory of Frances E. Lund, please click here.